Optimization minimum solvent consumption

Little has been said concerning the column diameter which, unfortunately, is an aspect of column technology that involves extensive theoretical discussion which is probably not appropriate here. Each column that is optimized to analyze a particular sample in the minimum time and with the minimum solvent consumption will also have an optimum diameter. The optimum column diameter... 

The reader will find here a complete mathematical development of the models of chromatography and other physical laws which direct the chemical engineer in the design and scale-up of chromatographic processes. For preparative chromatographic separations, our ultimate purpose is the optimization of the experimental conditions for maximum production rate, minimum solvent consumption, or minimum production cost, with or without constraints on the recovery yield. The considerable amormt of work done on this critical topic is presented in the... 

The counter-current pattern of adsorption and desorption favors high removal efficiencies. Desorption of the adsorbed solvents starts after the delay required to heat the activated carbon bed. The specific steam consumption increases as the residual load of the activated carbon decreases (Figure 22.1.6). For cost reasons, desorption is not run to completion. The desorption time is optimized to obtain the acceptable residual load with a minimum specific steam consumption. The amount of steam required depends on the interaction forces between the solvent and the activated carbon. The mixture of steam and solvent vapor from the adsorber is condensed in a condenser. If the solvent is immiscible with water the condensate is led to a gravity separator (making use of the density differential) where it is separated into a aqueous and solvent fraction. 

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