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Optimising diffusion parameters

The aim is for the signal intensity in trace B to be -10% of reference trace A for the solutes of interest as this will represent the final data point in the full diffusion experiment (Fig. 9.20). [Pg.317]

Ultimately, one may need to alter A, S and Gmax to achieve optimum signal decay profiles. The simulation of diffusion decay profiles can be usefully employed when setting-up diffusion experiments on new systems by suggesting appropriate initial parameters prior to optimisation. Typical values for A are milliseconds to hundreds of milliseconds and those for S are in the range 1-10 ms. [Pg.319]

Besides measurements, there are potential benefits in the observation of other nuclides for diffusion measurements. There may be fewer problems with resonance overlap of different species or less interference from solvent or impurity resonances, for example, or the compound of interest may simply lack hydrogen as is often the case with counter-ions. In this case, one should be aware that optimum parameters for measurement may not be suitable for nuclides of lower magnetogyric ratio, 7. This is because the total effective gradient strengths employed also depend on this parameter and, as can be seen from the Stejskel-Tanner equation (Eq. (9.6)), the degree of attenuation of resonance intensity will be reduced as 7 becomes smaller. This is illustrated in Fig. 9.23 where the decay profiles for four different nuclides are shown, having been calculated with identical diffusion parameters but with the appropriate 7 [Pg.319]


As mentioned, all reaction models will include initially unknown reaction parameters such as reaction orders, rate constants, activation energies, phase change rate constants, diffusion coefficients and reaction enthalpies. Unfortunately, it is a fact that there is hardly any knowledge about these kinetic and thermodynamic parameters for a large majority of reactions in the production of fine chemicals and pharmaceuticals this impedes the use of model-based optimisation tools for individual reaction steps, so the identification of optimal and safe reaction conditions, for example, can be difficult. [Pg.199]

For the transport parameter optimisation the set of 66 data points for both catalysts were used. These sets included data for binary cases (pure gases in both compartments) and ternary cases (pure gas in one compartment and a binary mixture in the other compartment). In Figure 4 the experimental net volumetric diffusion fluxes are compared with calculated values based on the optimum sets of transport parameters. It can be seen that experimental and... [Pg.136]

The parameters defined in this chapter are divided into model parameters and evaluation parameters. Model parameters are porosity, voidage and axial dispersion coefficient, type and parameters of the isotherm as well as mass transfer and diffusion coefficient. All of them are decisive for the mass transfer and fluid flow within the column. They are needed for process simulation and optimisation. Therefore their values have to be valid over the whole operation range of the chromatographic process. Experimental as well as theoretical methods for determining these parameters are explained and discussed in Chapter 6. [Pg.47]

A graphical approach was also used by Millet and Pons to analyse anisotropy of rotational diffusion in proteins. The values of Z)j and DJD compatible with R IRi ratios are presented as a contour plot. The intersection of the contour plots for different residues provides the values of anisotropy parameters compatible with experimental data. The obtained parameters can be used as starting values for further optimisation. The method is apphcable to axially symmetric rotation. A combination of approximate and exact methods was used by Ghose et al. to reduce the computational time of the determination of rotational diffusion tensor from NMR relaxation data. The initial values of the tensor components and its orientation are evaluated from the approximate solution, which substantially reduces the search space during the exact calculations. The method was applied for the estimation of relative domain orientation of a dual domain protein. [Pg.292]

In addition to the diffuser opening angle, y, the key parameters allowing the optimisation of turbulent mixing efficiency, in a diffuser-confusor reactor, are the diffuser to confusor diameter ratios dj/d and the length of the diffuser-confusor section L /dj. [Pg.36]

In order to optimise the conditions of fast processes, it is reasonable to reveal a correlation between the geometrical parameters of a tubular turbulent diffuser-confusor device, the dynamics and physical parameters of its liquid flows, and average values of the characteristic turbulent mixing time. [Pg.43]

Modelling of the polymer particle growth process [82] has resulted in the conclusion that diffusion limitations are the single reason for the wide polydispersity of synthesised polymers. The model has demonstrated that the main transport limitations localise on the level of macroparticles. Modelling results are confirmed by data obtained in gas and liquid polymerisation experiments on titanium-magnesium catalysts. Authors also consider that the wide polydispersity of polymers can be explained by the existence of more than one type of active centre. Each specific type is responsible for a certain portion of polymer with a different MWD. However, the authors did not succeed in characterising the active centre [82] because it required the optimisation of many kinetic parameters. [Pg.173]

The fundamental analysis of fast polymerisation processes in turbulent flows has been carried out in this chapter. Kinetic parameters of polymerisation and polymer-analogous processes become available for calculation as the decrease of diffusion limitations in polymer synthesis reactions is achieved by turbulent mixing intensification in the reaction zone. This approach also opens ways to optimise the molecular characteristics of the forming polymer products, as well as tools to control the entire process. Results of the theoretical description of the turbulent mixing process of a reaction zone in a diffuser-confusor-type reactor provide opportunities for control of fast polymerisation processes. [Pg.199]

Observing the above equation, we note that measuring the time lag does not necessarily provide us with the information about the functional form of the diffusion coefficient. This is usually what we would like to obtain for a given system. One could, however, choose a functional form for D containing one or more parameters, and then by measuring the time lags at various values of the concentration of the supply reservoir we can do a nonlinear optimisation to extract those parameters for the assumed functional form of the diffusion coefficient. [Pg.722]

The principle of this type of solvent extraction is based on diffusion of solvent through seeds and subsequent solubilisation of oil. The most common solvents used in this process are alkanes with low boiling points such as hexane. The key parameter of this process is the rate of diffusion of the solvent into the oil body. This process is more efficient than its mechanical counterpart but involves use of volatile organic solvents (though their recuperation is highly optimised). [Pg.5]

A brief overview [4] is given next of one theory of DRS for particles that absorb IR radiation. Incident radiation from the spectrometer is focused onto the surface of the sample and reflected energy collected. The reflected energy can either be classified as specular or diffuse reflectance. Specular reflectance arises from energy that is reflected by the particles but is not absorbed. The energy that penetrates one or more particles and is collected is called diffuse reflectance. With these experimental parameters optimised, a high-quality spectrum is obtained. For some samples, the specular component can be large and difficult to avoid. This can lead to problems in the measurement of the... [Pg.170]

In order to unambiguously fix two force field parameters, in principle there is the need to decide on two experimental observables that the simulation should reproduce. In fact, we base our parameter optimisation on the free energy and entropy of hydration, for which reliable experimental data exist.This choice is partly based on the diffuse notion that the solvation free energy and entropy are important for the ion-specific effects encountered in aqueous solution. We also calculate the solvated ionic radius as a consistency check (and find good results for the effective size in the anionic case even without optimising for it). Here we... [Pg.243]

In order to correct for the survival probability within the IRT framework, a series of random flights simulations were done in which the survival probability was calculated as a function of the (a/R) ratio, with a being the encounter distance and R the spherical radius. Within the IRT algorithm a correction factor f was applied to the mutual diffusion (D ) coefficient and optimised until convergence was obtained for the survival probability across the (a/R) parameter space. The value of C was then plotted as a function of the (a/R) ratio and was found to obey the approximation of the form... [Pg.284]


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Diffusion parameter

Optimisation

Optimisation Optimise

Optimisation Optimised

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