Optical activity small molecules

A similar chiral stimuli-responsive, macromolecular helicity inversion was also observed for (R)- or (S)-68 bearing an optically active (1-(1-naphthyl)ethyl)carbamoyl group by interacting with optically active small molecules, such as (R)- and (S)-39 (Fig. 15) [126]. The ICD of (R)-68 or (S)-68 in DMF changed to almost a mirror image in the presence of an excess of (R)-or (S)-39, respectively. Thus, optically active 39 can be used to regulate the helix-sense of 68. 

A. Moskowitz, Adv. Chem. Phys., 4, 67 (1962). Optical Activity Small Molecules. 

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