Opportunities for Continuing Development

For effective process control of bioseparations, it is necessary to have reliable, repeatable, on-line measurements. The delays caused by off-line analysis can be prohibitive. Offline approaches also tend to result in increased labor and costs.31 Development of such sensors appears to offer promise as an area of research. Biosensors may be one solution, but the characteristics of a typical biosensor do not align well with those required for control. 

Tools to enable the coupling of quality control techniques with those required for process control are another interesting area for continued investigation. If the two tasks can be harmonized, less instrumentation may be needed. 

Mattiasson, B., and Hakanson, H. (1991). Measurement and control in down-stream processing. In Measurement and Control in Bioprocessing (K. G. Carr-Brion, ed.), Chapter 8, pp. 221-250. Elsevier Applied Science. 

Petrides, D., Sapidov, E., and Calandranis, J. (1995). Computer-aided process analysis and economic evaluation for biosynthetic human insulin production—A case study. Biotechnol. Bioeng. 48, 529-541. 

Buckley, P. S. (1992). Process Control Strategy and Profitability. Instrument Society of America, Research Triangle Park, NC. 

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