Opening reactions with organocopper compounds

Ft I r 36 R1 = OH. R2 - H 10 R = R2 - O also be opened with organocopper compounds, but this only occurs at room temperature 14 Selective reaction of dimethylcuprate with the triflate group is therefore possible by appropriate choice of the reaction temperature. 

While a large number of studies have been reported for conjugate addition and Sn2 alkylation reactions, the mechanisms of many important organocopper-promoted reactions have not been discussed. These include substitution on sp carbons, acylation with acyl halides [168], additions to carbonyl compounds, oxidative couplings [169], nucleophilic opening of electrophilic cyclopropanes [170], and the Kocienski reaction [171]. The chemistry of organocopper(II) species has rarely been studied experimentally [172-174], nor theoretically, save for some trapping experiments on the reaction of alkyl radicals with Cu(I) species in aqueous solution [175]. 

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