Ontogeny and Pharmacology

Because clinical investigation of new agents is not uniformly performed in newbornS/ infantS/ and children/ we have a poor understanding of the effect of ontogeny on the pharmacokinetics and pharmacodynamics of most drugs. However/ we can often anticipate age-related differences in pharmacokinetics and 

TABLE 233 Relative Gastrointestinal Absorption of Selected Drugs in Infants and Adults  

TABLE 23.4 Plasma Protein Binding of Selected Drugs in Cord Blood and Adult Blood  

FIGURE 23.2 Age-related changes in body composition. (Reproduced with permission from Kaufman RE, Pediatric pharmacology. In Aranda JV, Yaffe SJ, editors. Pediatric pharmacology, therapeutic principles in practice. Philadelphia WB Saunders 1992. p. 212-9.) 

FIGURE 23.3 The distribution volume of sulfisoxazole in newborns, infants, cliildren, and adults. (Data from Routledge P. J Antimicrob Chemother 1994 34(suppl A) 19-24.) 

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