One Active and m Regulatory Sites

The generalization of the model in Section 8.6 to three or more regulatory sites is quite straightforward. We still assume a two-conformation enzyme (L, H) with one active site and m identical (in the strict sense) regulator sites. 

Since we have only one active site, the BI for this site, at = 0, is the same as in previous sections, i.e.. 

For computational purposes we use again the transformation of variables, as in Section 8.5, to obtain the functions 

As before, these parameters produced an inverted S-shaped regulatory ciuv e, while yAR yRR - 385 (for the first pair of Rs). However now, 

We see that the correlations grow rapidly with m, leading to very sharp inverted S-shaped regulatory curves. 

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