Seizures ondansetron

Other than slow taper, no consistently effective treatment to alleviate withdrawal symptoms has been reported. Although several compounds have been studied (e.g., b-blockers, clonidine, carbamazepine, abercamil, ondansetron), results have been contradictory ( 250). Carbamazepine, however, may be useful in seizure-prone patients (251). Valproate (VPA) has also been reported to benefit patients undergoing BZD discontinuation after long-term dependence ( 252), which may be related to VPA s potential anxiolytic properties, its ability to alleviate withdrawal phenomena, or both. The azaspirone anxiolytic buspirone has been reported ineffective in suppressing withdrawal symptoms, particularly in long-term BZD users (253, 254). Hydroxyzine has also been found beneficial in treating patients for lorazepam withdrawal (255). 

Treating of infections will reduce one potential promoter of catabolism and prevent further episodes of decompensation. Treatment should be administered with an effective antipyretic and seizure management and, in some cases, antiemetic drugs, such as ondansetron. When treating seizures, avoid drugs that may inhibit mitochondrial function such as valproic acid or chloral hydrate [17]. 

A 4-year-old boy developed dystonic posturing of both upper limbs and clenching of teeth after receiving intravenous ondansetron 2 mg (0.13 mg/kg) [33 ]. He then had generalized tonic-clonic seizures lasting for few minutes, followed by drowsiness. 

Patel A, Mittal S, Manchanda S, Philiyel JM. Ondansetron-induced dystonia, hypoglycemia, and seizures in a child. Ann Pharmacother 2011 45 e7. 

Ondansetron has both proconvulsant and anticonvulsant effects in animals. Seizures have been reported in two women and one man (ages 38-56 years) after... 

Although other 5HT3 receptor antagonists (particularly ondansetron) have been previously reported to cause seizures, in this case the role of palonosetron was uncertain. 

George M, Al-Duaij N, O Donnell KA, Shannon MW. Obtundation and seizure following ondansetron overdose in an infant. Clin Toxicol (Philadelphia) 2008 46 1064-6. 

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