Oncogenes table

TABLE 5.22 Important Oncogenes and Tumor Suppressor Genes in Human Cancers... 

Some established cell lines were derived from malignant tissue. Many of these cell lines can form tumors when injected into susceptible animals. Other established cell lines are not Uunorigenic. However, exposure to carcinogens, and irradiation can cause these cells to form tumors in susceptible animals. In addition, transformation can be caused by spontaneous mutations, by growth factors, and by viral (or oncogenic) transformation (Table 6). Malignant transformation is defined as consisting of the series of events that cause normal cells to develop the capacity to form tumors. 

TABLE 85-1. Examples of Oncogenes and Tumor-Suppressor Genes... 

Figure 3. Distribution of RVIS in different types of genes in repopulating hematopoietic cells of T and 2" cohort animals. RVIS were classified as in Table 1. Note the strong overrepresentation of RVIS into oncogenes already in the first cohort, which even further increases after serial transplantation.

Table 21.3 Some oncogenes, their protein products and functions...

Following lifetime feeding studies at the prescribed treatment levels, veterinary pathologists examine approximately 50 tissues from each animal for the presence of tumors or other evidence of tissue damage. The results of such oncogenicity studies in mice, conducted with the selected triazine herbicides, are presented in Table 25.6. 

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