Omeprazole SSRIs

OMEPRAZOLE SSRIs - FLUVOXAMINE 1 fluvoxamine levels with loss of therapeutic efficacy Inhibition of CYP1A2-mediated metabolism Monitor for lack of therapeutic effect. When omeprazole is withdrawn, monitor for fluvoxamine toxicity... 

C19 Omeprazole, SSRIs Phenytoin, topiramate, (Rj-warfarin... 

Omeprazole, like cimetidine, can impair benzodiazepine metabolism and lead to adverse effects (SEDA-18, 43). Other drugs, including antibiotics (erythromycin, chloramphenicol, isoniazid), antifungal drugs (ketoconazole, itraconazole, and analogues), some SSRIs (fluoxetine, paroxetine), other antidepressants (nefazodone), protease inhibitors (saquinavir), opioids (fentanyl), calcium channel blockers (diltiazem, verapamil), and disulfiram also compete for hepatic oxidative pathways that metabolize most benzodiazepines, as well as zolpidem, zopiclone, and buspirone (SEDA-22,39) (SEDA-22,41). 

An isolated report describes a fatal multiple drug intoxication involving citalopram and cocaine. It was suggested that SSRIs and cocaine bind to the same receptor site and their concurrent use may have an additive effect through inhibition of serotonin reuptake. The patient also took other drugs including omeprazole, which may have further potentiated the effects of citalopram. ... 

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See also in sourсe #XX -- [ ]

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