Omeprazole Clarithromycin

Triple therapy (omeprazole/clarithromycin/amoxiclllin)- Omeprazole 20 mg plus clarithromycin 500 mg plus amoxicillin 1000 mg each given twice/day for 10 days. If an ulcer is present at the initiation of therapy, continue omeprazole 20 mg for an additional 18 days. 

Amoxicillin 1 g three times a day + omeprazole 20 mg twice a day Clarithromycin 500 mg three times a day + omeprazole 40 mg every day... 

Antibiotics clarithromycin, erythromycin Others omeprazole, cisapride, dapsone, lavastatin... 

The therapy prescribed is a 1-week triple therapy regimen consisting of amoxicillin, clarithromycin and omeprazole against Helicobacter pylori infection. 

III. Eradication of Helicobacter pylori C. This microorganism plays an important role in the pathogenesis of chronic gastritis and peptic ulcer disease. The combination of antibacterial drugs and omeprazole has proven effective. In case of intolerance to amoxicillin (p. 270) or clarithromycin (p. 276), metronidazole (p. 274) can be used as a substitute. Colloidal bismuth compounds are also effective however, the problem of heavy-metal exposure compromises their long-term use. 

Dual therapy - In combination with clarithromycin (omeprazole) or amoxicillin (lansoprazole). 

Clarithromycin/Omeprazole/Amoxicillin- 500 mg clarithromycin, 20 mg omeprazole, and 1 g amoxicillin every 12 hours for 10 days. In patients with an ulcer present at the time of initiation of therapy, an additional 18 days of omeprazole 20 mg once daily is recommended for ulcer healing and symptom relief. 

Clarithromycin/Omeprazole - 500 mg clarithromycin 3 times/day (every 8 hours), and 40 mg omeprazole once daily (every morning) for 14 days. An additional 14 days of 20 mg omeprazole once daily is recommended for ulcer healing and symptom relief. 

Drugs that may affect indinavir include didanosine, aldesleukin, anticonvulsants, atazanavir, nelfinavir, nevirapine, omeprazole, rifapentine, ritonavir, clarithromycin, azole antifungals, rifamycins, delavirdine, efavirenz, St. John s wort. 

Drugs that may affect tacrolimus include nephrotoxic agents (aminoglycosides, amphotericin B, cisplatin, cyclosporine), antifungals, bromocriptine, calcium channel blockers, cimetidine, clarithromycin, danazol, diltiazem, erythromycin, methylprednisolone, metoclopramide, carbamazepine, phenobarbital, phenytoin, rifamycins, cisapride, chloramphenicol, metronidazole, nefazodone, omeprazole, protease inhibitors, macrolide antibiotics, fosphenytoin, and St. John s wort. 

Amoxycillin 500 mg thrice daily plus clarithromycin 500 mg twice daily, plus omeprazole 20 mg twice daily... 

Clarithromycin 500 mg twice daily plus metronidazole 400 mg twice daily plus omeprazole 20 mg twice daily (or lansoprazole 30 mg twice daily or pantoprazole 40 mg twice daily or rabeprazole 20 mg twice daily or ranitidine bismuth citrate... 

Intermittent claudication PO 100 mg twice a day at least 30 min before or 2 hr after meals. 50 mg twice a day during concurrent therapy with clarithromycin, diltiazem, erythromycin, fluconazole, fluoxetine, omeprazole, or sertraline. 

The study population consisted of CYP2C19-genotyped patients infected with H. pylori who had completed initial treatment with omeprazole 20 mg or lansoprazole 30 mg twice daily, and clarithromycin 200 mg and amoxicillin 500 mg three times a day for 1 week. Patients in whom the infection was not eradicated after initial treatment were retreated with lansoprazole 30 mg and amoxicillin 500 mg four times a day for 2 weeks. 

Drugs that may inhibit cytochrome P450 metabolism of other drugs include amiodarone, androgens, atazanavir, chloramphenicol, cimetidine, ciprofloxacin, clarithromycin, cyclosporine, delavirdine, diltiazem, diphenhydramine, disulfiram, enoxacin, erythromycin, fluconazole, fluoxetine, fluvoxamine, furanocoumarins (substances in grapefruit juice), indinavir, isoniazid, itraconazole, ketoconazole, metronidazole, mexile-tine, miconazole, nefazodone, omeprazole, paroxetine, propoxyphene, quinidine, ritonavir, sulfamethizole, verapamil, voriconazole, zafirlukast, and zileuton. 

For the eradication of Helicobacter pylori in peptic ulceration, omeprazole may be combined with antibacterials in dual or triple therapy. Effective triple therapy regimens include omeprazole 20 mg twice daily combined with amoxycillin 500 mg and metronidazole 400 mg, both three times daily clarithromycin 500 mg and metronidazole 40 mg (or tinidazole 500 mg) both twice daily or with amoxycillin 1 g and clarithromycin 500 mg both twice daily. These regimens are given for 1 week. Dual therapy regimens, such as omeprazole 40 mg daily with either amoxycillin 750 mg to 1 g twice daily or clarithromycin 500 mg three times daily, are less effective and must be given for 2 weeks. Omeprazole alone may be continued for a further 4r-8 weeks [1]. 

D. Markham, and D. McTavish, Clarithromycin and omeprazole As Helicobacter pylori associated gastric disorders. Drugs 51 161-178, 1996. 

H. pylori infections are normally treated by a triple therapy course over a week, namely two antibiotics plus an acid inhibitor, for example amoxicillin, clarithromycin and a PPI such as omeprazole. 

CLARITHROMYCIN PROTON PUMP INHIBITORS -OMEPRAZOLE t efficacy and adverse effects of both drugs t plasma concentration of both drugs No dose adjustment recommended. Interaction considered useful for Helicobacter pylori eradication... 

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