Olprinone

CJH4N2O 107-91-5) see Alloputinol Amrinone Ethionamide Milrinone Nevirapine Olprinone hydrochloride Protionamide cyanoacetic acid... 

C2H,BrMg 925-90-6) see Amfebutamone Dicthylstilbestrol Elhylestrenol Etretinate Fomocaine Indanorex Ketobemidone Mepivacaine Methadone Methallenestril Methohexital Normethadone Olprinone hydrochloride Retinol cthylmalonic acid diethyl ester see under diethyl ethylmalonate ethylmercaptan... 

CYP450 system Anagrelide enhanced the inhibition of platelet aggregation by aspirin and is an inhibitor of cyclic AMP PDE III (may exaggerate the properties of milrinone, enoximone, amrinone, olprinone, and cilostazol). 

Nomura, Y., Horimoto, H., Mieno, S., Nakahara, K., Okawa, H., Yoshida, M., and Shinjiro, S. 2003. Repetitive preischemic infusion of phosphodiesterase III inhibitor olprinone elicits cardioprotective effects in the failing heart after myocardial infarction. Mol. Cell. Biochem. 248 179-184. 

CN l,2-dihydro-5-imidazoi l,2-[Pg.1482]

Olprinone is an inhibitor of phosphodiesterase type III, and has a positive inotropic effect. It is given intravenously and is mostly eliminated by the kidneys. Its pharmacological effects have been reviewed (1). Its major adverse effects are cardiac dysrhythmias and thrombocytopenia, the latter with a reported incidence of 0.43%. 

Mizushige K, Ueda T, Yukiiri K, Suzuki H. Olprinone a phosphodiesterase III inhibitor with positive inotropic and vasodilator effects. Cardiovasc Drug Rev 2002 20(3) 163-74. 

Olprinone hydrochloride (E), a cardiotonic and vasodilator acting as PDE Ill-inhibitor, synthesized by the following route starting with 2-amino-5-bromopyridine (X) ... 

Anagrelide is a cyclic AMP phosphodiesterase III inhibitor, and consequently has positive inotropic effects. The manufacturer recommends against its concurrent use with other phosphodiesterase III inhibitors, because of the potential increased inotropic effects, and they specifically mention amrlnone, cllostazol, enoximone, milrinone, and olprinone. ... 

Indeed, they are known for their anxiolytic, cardiovascular, analgesic, antihypertensive, and neuroleptic among other activities. These heteroclyclic skeleton forms the core structure of several drug molecules like zolpidem used in the treatment of insomnia, alpidem, an anxiolytic agent, olprinone for the treatment of acute heart failure, minodronic acid useful for the treatment of osteoporosis, and zolimidine used for the treatment of peptic ulcer. Besides, imidazo[l,2-a] pyridines and pyrimidines are also attractive due to their physicochemical properties such as fluorescent activity [128]. 

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