Oligosaccharides, continuous flow synthesis

Koichi Fukase et al. reported an example of oligosaccharide synthesis by combining microreactors and an isolation strategy called synthesis based on affinity separation (SAS) [72, 73], The glycosylation was carried out under continuous flow, and the mixture was directly sent to the stainless steel affinity column, and the flow channel was switched to wash the column with CH2C12. The labeled disaccharide was trapped in the column later to be eluted with a mixture of CH2C12 and methanol to obtain the isolated oligosaccharide product. 

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