Oligosaccharide synthesis challenges

The challenge for developing methods for synthesizing oligosaccharides, notably for complex oligosaccharides, that can be scaled up to an industrial level is obvious, based on the use of substrates and enzymes that are available at reasonable cost and purity. Strategies for oligosaccharides synthesis include ... 

The stereoselective formation of a glycosidic bond is the key feature of oligosaccharide synthesis. Despite the many powerful glycosylation methods that have been developed, there are still a few glycosidic linkages that are difficult to synthesise. For example, the / -mannosidic bond presents a synthetic challenge because the anomeric effect favours the formation of... 

CHALLENGES AND LIMITATIONS IN SOLUTION-PHASE OLIGOSACCHARIDE SYNTHESIS... 

The selective preparation of 1,2-czs-linkages in the D-manno and L-rhamno series is still one of the major challenges in oligosaccharide synthesis. Several new and promising approaches deal with this problem [59]. Since a number of pyru-vated oligo- and polysaccharides also contain o-mannosyl and j -L-rhamnosyl residues (Table 1), eCBcient strategies for their preparation are also needed here. 

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