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Oligodeoxyribonucleotides synthesis

The fundamental problem of oligodeoxyribonucleotide synthesis is the efficient formation of the intemucleotidic phosphodiester bond specifically between C-3 and C-5 positions of two adjacent nucleosides. Any functional group (NH of nucleic base the other OH of deoxy-... [Pg.215]

Another convenient phosphitylating reagent for use in an oligodeoxyribonucleotide synthesis based on the phosphoramidite approach is bis(tetrazolyl)morpholinophosphine. This is generally prepared in situ from morpholinophosphordichloridite containing di-isopropylethylamine and two equivalents of tetrazole in dichloromethane/pyridine at... [Pg.33]

Krotz A, Klopchin P, Walker K, Srivatsa S, Cole D, Ravikumar V. On the formation of longmers in phosphorothioate oligodeoxyribonucleotide synthesis. Tetrahedron Lett 38 3875-3878, 1997. [Pg.526]

Reese, C. B. and Skone, P. A. (1984) The protection of thymine and guanine residues in oligodeoxyribonucleotide synthesis. J Chem. Soc Perkin Trans /, 1263-1271. [Pg.142]

Zarytova, V, F, and Knorre, D. G. (1984) General scheme of the phospho-tnester condensation in the oligodeoxyribonucleotide synthesis with aiylsulfonyl chlorides and arylsulfonyl azolides. Nucl. Acids Res 12,2091-2110. [Pg.418]

Nucleotidic Coupling and Related Reactions. BOP has been used as a condensing agent to promote internucleotidic bond formation in phosphotriester oligodeoxyribonucleotide synthesis. ... [Pg.39]

See other pages where Oligodeoxyribonucleotides synthesis is mentioned: [Pg.531]    [Pg.73]    [Pg.243]    [Pg.244]    [Pg.244]    [Pg.246]    [Pg.250]    [Pg.258]    [Pg.506]    [Pg.187]    [Pg.221]    [Pg.203]    [Pg.249]    [Pg.20]    [Pg.21]    [Pg.33]   
See also in sourсe #XX -- [ Pg.64 ]



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Oligodeoxyribonucleotide

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