Oligo-L-lysines

Fig. 4. Amide f FTIR (top) and VCD (bottom) of thermally further unfolded random coil peptide, oligo-L-lysine, at 5°C (solid line), 50°C (dashed) and 75°C (dash-dot). Low temperature results reflect the polymer spectrum (Fig. 2, bottom), but with somewhat reduced intensity. Higher temperatures result in an IR frequency shift and loss of VCD amplitude, indicating a loss of structure. Measured amplitudes shown. Reprinted from Keiderling, T. A., Silva, R. A. G. D., Yoder, G., and Dukor, R. K. (1999b). Bioorg. Med. Chem. 7, 133-141. 1999, with permission from Elsevier Science.

Fig. 55. Linear oligo-L-lysine bearing aryl mannosides (503) and the quinic acid bioisostere of mannose (504).367,368...

Steiner LA, Eisen HN (1967) Sequential changes in the relative affinity of antibodies synthesized during the immune response. J Exp Med 126 1161-1183 Stryer L, Griffith OH (1965) Aspin-labeled hapten. Proc Natl Acad Sci USA 54 1785-1791 Stupp Y, Paul WE, Benacerraf B (1971 a) Structural control of immunogenicity. II. Antibody synthesis and cellular immunity in response to immunization with mono-8-oligo-L-lysines. Immunology 21 583-594... 

Wang J, Gibson MI, Barbey R, Xiao SJ, Klok HA (2009) Nonfouling polypeptide brushes via surface-initiated polymerization of N-epsilon-oligo(ethylene glycol)succinate-L-lysine N-carboxyanhydride. Macromol Rapid Commun 30 845-850... 

Figure 11.22 (a) Cholesteryl-oligo(L-lactic acid)-(lysine) G2 amphiphiles and (b) variations... 

Furthermore, enzymatic hydrolysis of model isopeptides N -oligo(L-methionyl)-l-lysine from Bio-beads13031 by pepsin, chymotrypsin, cathepsin C (dipeptidyl peptidase IV) and intestinal aminopeptidase N was investigated using high-performance liquid chromatography to identify and quantify the hydrolysis products 3041. 

The sequence analysis, tacticity, primary and secondary structure, influences of (a) cis-trans isomerization, (b) neighboring residue effects, and (c) type and concentration of solvent on chemical shifts for a number of synthetic polypeptides have been reported by Kricheldorf and coworkers. The investigated polypeptides (excluding homopolyglycine which is usually considered as a polyamide) include various poly-, oligo-, and copolypeptides (10, 13, 18-19, 20-23), and particularly polymers based on glycyl-glycine units, (15, 16, 21, 24) D- and L-amino acids (17, 25-28), and L-lysine and iso-L-lysine (29). 

OLIGO(PEPTE)ES) OF BASIC l-AMINO ACIDS (LYSINE, ORNITHINE, ARGININE, HISTIDINE) 8.2,10.1. Linear Oligoipeptides) h[nhchrco] oh... 

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