Olfactory bulb early learning

Sullivan, R. M. and Leon, M. (1986) Early olfactory learning induces an enhanced olfactory bulb response in young rats. Brain Res. 392, 278-282. 

Woo, C. C., Coopersmith, R. and Leon, M. (1987) Localized changes in olfactory bulb morphology associated with early olfactory learning. J. Comp. Neurol. 263, 113-125. 

The brain sites that are concerned with early olfactory learning of social cues include the olfactory bulb. In rat pups blocking the glutamate receptors... 

Sullivan RM, Zyzak DR, Skierkowski P, Wilson DA. 1992. The role of olfactory bulb norepinephrine in early olfactory learning. Brain Res Dev 70 279-282. 

The determination of fhe embryonic "critical period of development" for the brain structures involved in learning and memory processes in mice is based on the original work by Rodier (1976). This study identified fhe embryonic time frames for peak neurogenesis and neuroepithelial proliferation for cerebral corfex, hippocampus, septum, amygdala, corpus striatum, thalamus, hypothalamus, cerebellum, and olfactory bulb as the period from embryonic day E14 fhrough E17. Rodier documented almost 40 years ago that the specific time of the central nervous system (CNS) insult is an important factor in subsequent effects on both anatomy and behavior. Therefore, this early work established what we refer to as the embryonic "critical period of development." The report suggested that the behavioral effects of toxicants such as benzo(a)pyrene (B(a)P) are similar in both rats and mice. This study was one of the first to demonstrate that mice could be used successfully as subjects in a variety of behavioral evaluation experiments. 

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