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OKT3 nephrotoxicity

Abramowicz D, De Pauw L, Le Moine A, Sermon F, Surquin M, Doutrelepont JM, Ickx B, Depierreux M, Vanherweghem JL, Kinnaert P, Goldman M, Vereerstraeten P. Prevention of OKT3 nephrotoxicity after kidney transplantation. Kidney Int Suppl 1996 53 S39-43. [Pg.2400]

OKT3 nephrotoxicity From acute tubular necrosis to hemolytic-uremic... [Pg.459]

Prevention of OKT3 nephrotoxicity after kidney transpiantation... [Pg.472]

The cytokines released after the first OKT3 injection probably play a major role in the pathogenesis of this type of OKT3 nephrotoxicity. Indeed, injections in rodent and man of recombinant IL-2 [134,135], IFN-y [136, 137] or TNF-a [138] have been consistently reported to induce renal dysfunction, sometimes in association with acute tubular necrosis. The following hypotheses can be put forward to account for OKT3-induced renal dysfunction in kidney transplant recipients ... [Pg.472]

Toussaint C, De PauwUVereerstraeten P, Kinnaert P, Abramowics D, Goldman M Possible nephrotoxicity of the prophylactic use of OKT3 monoclonal antibody after cadaveric renal transplantation. Transplantation 1989,48 524-526... [Pg.697]

Wever PC, Roest RW, Wolbink-Kamp AM, et al. OKT3-induced nephrotoxicity is associated with release of group II secretory phospholipase A2. Eur J CUn Invest 1996 26 873-878. [Pg.889]

In the first part of this chapter, we review the renal toxicity of the cytokines currently in clinical use. In the second part, we describe the cytokine-mediated nephrotoxicity associated with the use of the OKT3 mono-... [Pg.459]

To get further insights into the anti-CD3-induced nephrotoxicity, we investigated in a murine model the abihty of anti-CD3 mAb to directly damage native kidneys. For this purpose, we injected mice with the hamster anti-mouse CD3 mAb 145-2C11 [153]. Like OKT3, this mAb is immunosuppressive [154] and first induces a transient release of several cytokines in the circulation, such as IL-2, IL-6, TNF-a, and IFN-y [102, 155, 156]. Histologic analysis revealed signs of tubular ne-... [Pg.472]

The initial lymphocyte and monocyte activation induced by the OKT3 mAh is responsible for first dose reactions, which include a transient nephrotoxic effect in kidney, transplant recipients. Moreover, activation of the common pathway of coagulation occurs at the initiation of OKT3 therapy. When additional predis-... [Pg.475]

See other pages where OKT3 nephrotoxicity is mentioned: [Pg.470]    [Pg.472]    [Pg.474]    [Pg.475]    [Pg.470]    [Pg.472]    [Pg.474]    [Pg.475]    [Pg.882]    [Pg.1634]    [Pg.1634]    [Pg.460]    [Pg.469]    [Pg.470]    [Pg.39]   
See also in sourсe #XX -- [ Pg.469 , Pg.470 , Pg.471 , Pg.472 , Pg.473 , Pg.474 ]



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Nephrotoxicity

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