Ointment crystalline structure

Drug manufacturers need to confirm that each batch of API has the same crystalline structure, and that this crystal form remains constant throughout the formulation and life of the drug product (particularly for solid oral dosage forms, powders, creams, ointments, and suspensions). The crystalline structure can also place physical constraints on the ability to manufacture a particular dosage form. For example, needle-shaped crystals tend to entangle and often do not flow well in manufacturing equipment. This can cause formulation of "hot spots," with... 

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