Ofamino acids

In nature, aminotransferases participate in a number of metabolic pathways [4[. They catalyze the transfer of an amino group originating from an amino acid donor to a 2-ketoacid acceptor by a simple mechanism. First, an amino group from the donor is transferred to the cofactor pyridoxal phosphate with formation of a 2-keto add and an enzyme-bound pyridoxamine phosphate intermediate. Second, this intermediate transfers the amino group to the 2-keto add acceptor. The readion is reversible, shows ping-pong kinetics, and has been used industrially in the production ofamino acids [69]. It can be driven in one direction by the appropriate choice of conditions (e.g. substrate concentration). Some of the aminotransferases accept simple amines instead of amino acids as amine donors, and highly enantioselective cases have been reported [70]. 

Lejon et al., (3)a derivatives ofamino acids in octanol/water dG = RTln f f = fraction buried/accessible amino acids HPLC retention times for nine combinations of three different pH and three eluent mixtures (9 descriptors)... 

Dzygiel, P., Wieczorek, P., Mathiasson, L., Jonsson, J. A. (1998). Enrichment ofamino acids by supported liquid membrane extraction using Aliquat 336 as a carrier. Anal. Lett., 31, 1261-74. 

Wieczorek, P., Tomaszewska, M. (1997). Transport ofamino acids through liquid membranes supported on novel poly(vinylidenefluoride) porous flat-sheet matrix. Solvent Extr. Ion. Exc., 15, 879-94. 

As a result of approximating the frequency distributions by normal distribution, one obtains the average deviation i,pthe sample standard deviation o,y,and the number ofamino acid residues / found in the transmembrane (y= 1) and extramembrane (y = 2) state Njj. All of these data are shown in Table 4. 

W. S. Hancock, ed.. Handbook of HPLC for the Separation ofAmino Acids, Peptides and Proteins, Vols. I and II, CRC Press, Boca Raton, FL, 1984. 

Table 9.10 Metabolic fates of the carbon skeletons ofamino acids...

---