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Of steroid moiety

The synthetic procedure developed for the preparation of active fonns of vitamin D analogues was applied to the synthesis of various natural steroids by the reaction of steroid moieties with phenyl sulfone derivatives described here. [Pg.504]

Na+/K+-ATPase. Figure 2 Specific Inhibitors of Na+/K+-ATPase. (a) Endogenous cardiac glycosides identified in mammals. Substances with a 5-membered lactone at position C17 of the steroid moiety are referred to as cardenolides, those with a 6-membered lactone as bufadienolides. (b) Palytoxin (C P NsO ) produced by corals of the genus Palythoa. [Pg.816]

Intermolecular [4C+2S] cycloaddition reactions where the diene moiety is contained in the carbene complex are less frequent than the [4S+2C] cycloadditions summarised in the previous section. However, 2-butadienylcarbene complexes, generated by a [2+2]/cyclobutene ring opening sequence, undergo Diels-Alder reactions with typical dienophiles [34,35] (Scheme 59). Also, Wulff et al. have described the application of pyranylidene complexes, obtained by a [3+3] cycloaddition reaction (see Sect. 2.8.1), in the inverse-electron-demand Diels-Alder reaction with enol ethers and enamines [87a]. Later, this strategy was applied to the synthesis of steroid-like ring skeletons [87b] (Scheme 59). [Pg.99]

The forerunner in the Co-catalyzed [2+2+2] cycloaddition domino processes was that identified by Vollhardt and colleagues [273], with their excellent synthesis of steroids. Reaction of 6/4-1 with [CpCo(CO)2] gave compound 6/4-3 with an aromatic ring B via the intermediate 6/4-2. In this process, trimerization of the three alkyne moieties first takes place, and this is followed by an electrocyclic ring opening of the formed cyclobutene to give o-quinodimethane. This then undergoes a Diels-Alder reaction to provide the steroid 6/4-3 (Scheme 6/4.1). [Pg.458]

Microwave-assisted Heck reactions have also been carried out with triflates as coupling partners, involving some very complex molecules. Winterfeld and coworkers have reported a multigram synthesis of a complex non-symmetrical bis-steroidal diene by microwave-promoted coupling of the corresponding alkene and triflate steroidal moieties (Scheme 6.8) [27]. [Pg.112]

Steroids and sterols represent an important class of drugs that are susceptible to oxidative degradation through the possession of alkene moieties. The oxidation of phenothiazines forms the sulfoxide moiety. [Pg.330]

Encouraged by the success of MUMBIs to synthesize biaryl ether macrocycles, we endeavored to combine this methodology with experience in steroid synthesis to obtain very large macrocycles with both peptide and steroid moieties (Fig. 21). These molecules bear no direct resemblance to any known natural products, but they do display a high degree of structural... [Pg.171]

In 2000, Szarka and coworkers reported some preliminary results on the facile synthesis of steroidal hydroxamic acid derivatives via the palladium-catalyzed function-ahzation of skeletons (138-141) possessing iodoaikene moieties (Scheme 65). [Pg.197]

Polyene cyclization in terpene and steroid synthesis is critically dependent on the terminator in order to generate useful functionalities for further modification of the products. Allyl- and propargylsilanes have proven their value in facilitation of the cyclization and generation of an exocyclic methylene and allene, respectively. Thus, a concise approach to albicanyl acetate [126] and the rapid construction of a tetracyclic precursor of steroids [127] are sufficient to demonstrate the concept. Again, a comparison of the substrates with a silyl group with those having a simple alkyl moiety is very enlightening. [Pg.113]

It is worth saying that both lacking of selectivity in the A4 olefinic moiety hydrogenation and increasing of the axial epimer in 3 keto-derivatives saturation following the donor steric demand are typical aspects of steroid reduction by means of complex hydrides8. [Pg.167]


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See also in sourсe #XX -- [ Pg.30 , Pg.486 ]




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Of steroids

Steroid moiety

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