Of daunomycin

Bernstein, A., Hurwitz, E., Maron, R., Arnon, R., Sela, M., and Wilchek, M. (1978) Higher antitumor efficacy of daunomycin when linked to dextran In vivo and in vitro studies. /. Natl. Cancer Inst. 60, 379-384. 

Komillowicz-Kowalska TK, Wrzosek M, Ginalska G, Iglik H, Bancerz R (2006) Identification and application of a new fungal strain Bjerkandera audusta R59 in decolorization of daunomycin wastes. Enz Microbial Technol 38 583-590... 

The effect of the position of side chains on the intercalation kinetics of anthra-quinones,101 which are related to the aromatic moiety of daunomycin (13), was studied with the stopped flow SDS sequestration technique. Guest molecules 14—17 can have two different intercalation modes, a classic mode where both side chains are located in the same groove of the DNA helix (14 and 16) or a threading mode where the side chains are located in opposite grooves of the DNA (15 and 17) (Scheme 7). The relative position of intercalated 14 with respect to the DNA bases was suggested to be the same as for 13. 

Chaires JB, Dattagupta ND, Crothers DM (1983) Binding of daunomycin to calf thymus nucleosomes. 

Chaires JB, Herrera JE, Waring MJ (1990) Preferential binding of daunomycin to 5-ATCG and 5-ATGC sequences revealed footprinting, titration experiment. Biochemistry 29 6145-6153 Chakrabarti S, Mahmood A, Kassis AI, Bump EA, Jones AG, Makrigiorgos GM (1996) Generation of hydroxyl radicals by nucleohistone-bound metal-adriamycin complexes. Free Radic Res... 

Figure 14 Diagram of the daunomycin-d(C6TAC6) complex showing the intermolecular interactions which include intercalation and hydrogen bonds. Note that there are two hydrogen bonds between 09 of daunomycin and N2 and N3 of 62.

Figure 5-23 Stereoscopic drawing showing a molecule of daunomycin (Fig. 5-22) intercalated between two base pairs in a molecule of double-helical DNA, d(CGTACG). Nitrogen and oxygen atoms are shown as dots. From Quigley et al.220 Both daunomycin and adriamycin (doxorubicin 14-hydroxy-daunomycin) are important but seriously toxic anticancer drugs.

Karukstis, K. K., E. H. Z. Thompson, J. A. Whiles, and R. J. Rosenfeld. 1998. Partitioning of daunomycin and doxorubicin in AOT reverse micelle Abstracts of 215th ACS National Meetil1i j3. 

Martin (1980) reported self-association of daunomycin (an adriamycin analogue). Therefore, the conjugated ADR is considered to work as a very good carrier of the physically entrapped ADR by providing speciLc interactions between the two ADR molecules as well as nonspeciLc hydrophobic interactions (Yokoyama et al., 1998). 

Martin, S. R. 1980. Absorption and circular dichroic spectral studies in the self-association of daunomycin. Biopolymersl 9 713-721. 

Duncan, R., P. Kopeckova-Rejmanova, J. Strohalm, I. Hume, H. C. Cable, J. Pohl, J. B. Lloyd, and J. Kopecek. 1987. Anticancer agents coupled1e(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates/itro. Br. J. Cancei55 165-174. 

SsDNA Intercalation of daunomycin into hybridised dsDNA on SPCE surface Chronopotentiometric stripping analysis + 1.0pA... 

A. Mukhopadhyay, B. Mukhopadhyay, R.K. Srivastava and S.K. Basu, Scavenger-receptor mediated delivery of daunomycin elicits selective toxicity towards neoplastic cells of macrophage lineage, Biochem. J. 284 (1992) 237-241. 

B. Mukhopadhyay, A. Mukhopadhyay and S.K. Basu, Enhancement of tumouricidal activity of daunomycin by receptor-mediated delivery in vivo studies, Biochem. Pharmacol. 46 (1993) 919-924. 

Fig. 4. Diagram of the body-fixed vector viewed along the DNA helical axis. A is the COM of the four bases as labeled (C6, G7, C19, G18). B is the COM of the sugar groups of G7 and G18 marked as F and E . C is the COM of daunomycin. AB is the body-fixed vector b and AC is d. p is the vector used to calculate an angle 0 described in Fig. 7.

Two dimensional (2D) Free Energy Landscape of Daunomycin Intercalation... 

Dano K. Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells. Biochim Biophys Acta 1973 323 466 483. 

These phenolic hydroxyls have been observed in the proton NMR spectrum of N-acetyldaunomycin in chloroform solution (83) though they are broadened out due to rapid exchange with solvent in the spectrum of daunomycin in H2O solution. We can therefore compare the H-6 and H-ll ring B hydroxyl chemical shifts of 12.3 and 11.5 ppm for the Nuc/D = 5.9 daunomycin poly(dA-dT) complex in aqueous solution (Figure 25) with the values of 13.86 and 13.15 ppm observed for N-acetyldaunomycin in nonpolar solution (83). 

Figure 25. The 360-MHz correlation proton NMR spectra of the daunomycin poly(dA-dT) complex in /M NaCl, lOmNi cacodylate, lOmM EDTA, 80% HaO— 20% 2H 20. Spectrum A corresponds to the Nuc/D = 11.8 complex, pH 6.0 at 67°C and Spectrum B corresponds to the Nuc/D = 5.9 complex, pH 6.05 at 57°C. The strong resonance corresponds to thymidine H-3 proton of the nucleic acid while the weaker resonances (designated hy asterisks) corresponds to hydroxyl protons at Positions 9 and 11 on Ring B of the anthracycline ring of daunomycin...

---