Of 4-Acylpyrazol-3-ones

There are several reports on condensation reactions of 4-acylpyrazol-3-ones with primary amines (70LA75, 81AJC1117, 90M1023, 98JMC4001, 00JCR(M)622, 02IJC(A)554, 03JHC963), two of which describe reactions with thiourea and 

The condensation between 4-acylpyrazol-3-ones 137a,b and n-propylamine to give 

Ri = H or Br, R = OH, CONH2, PhNH, Ph, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 4-MeOC6H4, 

The condensation of 4-acyl-l,2-dihydropyrazol-3-ones 145a c with ethylenedia- 

Analogous derivatives 151a-d were synthesized by a similar manner. 

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An indirect way of introducing a substituted aminohydroxypropyl group at position 1 of l,2-dihydropyrazol-3-ones was devised by Holzer, Ecker and co-workers (98JMC4001) (Scheme 8). The method consists of reacting the sodium salt of 4-acylpyrazol-3-ones 23a-l with excess epichlorohydrin and successively... 

Acylpyrazol-3-ones are the focus of research on potential antifungal agrochemicals and their metal extracting properties. 

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