Ocular penetration enhancers applications

The release kinetics data results indicated that liposome surface charge and bilayer fluidity are of minor importance for the interaction of liposomes with collagen shields. Moreover, the release kinetics of hydrophilic or lipophilic substance from collagen shield was similar for both liposome-encapsulated and nonencapsulated drug. Thus, these results suggest that there is no added value for combined application of collagen shields and liposomes. In another study, the combination of collagen shield and liposomes enhanced CsA ocular penetration but failed to provide sustained release compared to CsA liposomal suspension [121]. 

Gels The use of high-viscosity, water-soluble gel as a drug vehicle will prolong the therapeutic effect and enhance ocular penetration, reducing the frequency of application. However, only a limited number of dmgs are available as gel preparations (e.g. fusidic acid) and their use in equine practice is limited. 

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