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Barriers to ocular drug delivery. The presence of epithelial tight junctions and rapid drainage of the instilled drug solution by tears from the precorneal area result in the permeation of less than 5 percent of the applied dose of a drug.66,67 The cellular calcium levels and actin filaments of the cytoskeleton play a major role in the integrity of tight... [Pg.57]

See other pages where Precorneal barriers ocular drug delivery is mentioned: [Pg.91] [Pg.1195] [Pg.444] [Pg.149] [Pg.72] [Pg.302]

See also in sourсe #XX -- [ Pg.528 , Pg.529 ]