Abdominal cramps octreotide

Adverse effect of octreotide include nausea, vomiting, abdominal cramps and steatorrhea. 

Adverse effects of octreotide therapy include nausea, vomiting, abdominal cramps, flatulence, and steatorrhea with bulky bowel movements. Biliary sludge and gallstones may occur after 6 months of use in 20-30% of patients. However, the yearly incidence of symptomatic gallstones is about 1%. Cardiac effects include sinus bradycardia (25%) and conduction disturbances (10%). Pain at the site of injection is common, especially with the long-acting octreotide suspension. Vitamin B12 deficiency may occur with long-term use of octreotide. 

The most common adverse effects of octreotide therapy are gastrointestinal disturbances such as diarrhea, nausea, abdominal cramps, malabsorption of fat, and flatulence.xhese effects are dose dependent and can be seen within a few hours of the first octreotide injection. Gastrointestinal adverse effects occur in approx-... 

Gastrointestinal In 125 patients being treated with pelvic radiation for various cancers of the pelvis, randomly allocated to subcutaneous octreotide 100 micrograms on day 1 followed by depot octreotide 20 mg on days 2 and 29, or placebo, octreotide did not improve symptoms and may have worsened abdominal cramps, nocturnal bowel movement, and melena [38 "]. 

Octreotide is helpful in preventing or treating diarrhea and associated abdominal pain, but not muscle cramping or pain. 

---