Octanol/water partition coefficients methodology

Log P values can be measured experimentally or predicted from molecular structure. Experimental approaches run the gamut from the highly reliable and traditional shake-flask method to newer methodologies such as electrokinetic chromatographic methods that are rapid, accurate and precise, and can be automated. However, for validation purposes, partition coefficient data of large, structurally diverse datasets obtained from such systems should be compared with that from the standard octanol/water system. 

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