Ochratoxin risk assessment

Mycotoxins, selected ochratoxins, trichothecenes, ergot (No. 105,1990) Nephrotoxicity associated with exposure to chemicals, principles and methods for the assessment of (No. 119,1991) Neurotoxicity associated with exposure to chemicals, principles and methods for the assessment of (No. 60,1986) Neurotoxicity risk assessment for human health, principles and approaches (No. 223,2001)... 

B Zimmerli, R Dick. Ochratoxin A in table wine and grape-juice occurrence and risk assessment. Food Add Contain 13(6) 655-668, 1996. 

Zimmerli B, Dick R (1996) Ochratoxin A in Table Wine and Grape-Juice Occurrence and Risk Assessment. Food Addit Contam 13 655... 

Kuiper-Goodman T, Scott PM Risk assessment of the mycotoxin ochratoxin A. Biomed Environ Sci 1989 2 179-248. 

SUMMARY OF THE OUTCOME OF THE RISK ASSESSMENT BY THE INTERNATIONAL AGENCY FOR RESEARCH ON CANCER AND THE CODEX ALIMENTARIUS COMMISSION FOR AFLATOXINS, OCHRATOXIN A, AND PATULIN IN FOODS FOR HUMAN CONSUMPTION"... 

In this addendum, relevant findings for risk assessment published since the Committee s last evaluation (Annex 1, reference 153) are described. In addition, for aspects critical to the current re-evaluation (in particular, the mode of action of ochratoxin A as a kidney carcinogen), some of the data evaluated previously by this Committee are briefly summarized in order to set the context for the more recent information. 

In order to provide additional information for the risk assessment, the Committee performed benchmark dose (BMD) modelling using the carcinogenicity data on ochratoxin A from the rat bioassay performed by the NTP (National Toxicology Program, 1989). The occurrence of combined adenomas and carcinomas in the kidneys of the male rats (Table 2), as the most sensitive sex and species for kidney carcinogenicity of ochratoxin A, was considered the most appropriate data for modelling. 

European Commission (2004) Mechanisms of ochratoxin A induced carcinogenicity as a basis for an improved risk assessment. Final report. The European Commission 5th RTD Framework Programme, 1998-2002 Quality of Life and Management of Living Resources (QLK1-2001-01614). 

Walker, R. Larsen, J.C. (2005) Ochratoxin A previous risk assessments and issues arising. FoodAddit. Contain. 22(suppl. 1), 6-9. 

The new data, including data on mode of action of ochratoxin A In the kidney, do not indicate any reason to modify the previous risk assessment approach taken by JECFA. 

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