Occupancy Theory in Pharmacology

According to the occupancy theory, which has evolved chronologically from the original work of Clark [407,408], the drug effect is a function of two processes  

Therefore, the drug-receptor interaction follows the law of mass action and may be represented by the equation 

7 [drug molecules] + [receptor] [drug—receptor complex] 

When the total number of receptors rg is occupied, the effect will be maximal  

For drug concentration c(t) and a total receptor concentration rg we thus 

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