Occluded domains

The above computations for the fiee energy changes for composite latex particles have shown that only core-shell, inverted core-shell and hemispherical particles are stable in a thermodynamic sense. All of the other reported morphologies (e.g. sandwich-like , raspberry or confetti-like particles or occluded domains) are non-equilibrium, kinetically controlled structures, prepared... 

The 3x3 pm images in Fig. 7.17 show an L-TA crater on the surface of one of the isolated domains and confirm that the measurement is confined to this phase. L-TA results from several occluded domains and locations in the matrix are shown in Fig. 7.18. They show that, at approximately 115 °C, the matrix has... 

In the resting (closed) state, the ion channel is occluded by a hydrophobic girdle that constitutes a barrier to ion permeation. Agonist binding in the extracellular domain promotes a conformational change that results in a rotational movement of the M2 helices lining the pore, widening the pore by A. This results... 

A prerequisite for this model is the existence of both external and internal gates, i.e., protein domains that are capable of occluding access to the substrate binding site from the extracellular and intracellular environment, respectively. Little is known about such domains in this family of transporters. The molecular mechanisms governing the cooperative function of the putative gating domains also remain unknown. It could be predicted, however, that stabilization of the transporter in the outward-facing conformation in the absence of substrate but in the presence of Na+ requires a network of con-... 

During the cycle, large conformational changes take place within domains of the enzyme to make sure that calcium ions do not leak back into the cytoplasm but are occluded at binding sites within the SR membrane portion of the enzyme until such time that the enzyme s lumenal gate opens to release the ions to the lumen. 

ATP binds, crosslinking the N and P domains. The ATP s y-phosphate and its bound Mg + ion bend the P domain. The N-domain makes contact with the A domain in a strained conformation. Part of the Ml helix is pulled up and forms a barrier to Ca + ion exchange with the cytoplasm. Calcium ions are occluded. 

Other papers reported the phase separation behavior for the composition showing dual phase morphology [7,20,21,43-45], Delides et al. [43] proposed that the viscosity at the point of phase separation is sufficiently large enough to inhibit diffusion of the epoxy through the rubber (CTBN) and result in the generation of the occluded phase, which is the inclusion of epoxy domains within the rubbery phase. 

Vidano and Fischbach, 1978). Moreover, the relative intensities of the Raman bands at 1590 and 1350 cm-1 indicate that the graphite-like domains were roughly 60 A in diameter (Tuinstra and Koenig, 1970). This size of the carbon aggregates confirmed the hypothesis of occluded surfactant molecules in the mesostructured phosphate. 

The structure of the H8 helix and the adjacent sequence in 306-311 is essentially identical in the A and B chains of the crystal lattice (Fig. 4B). The differences in the computed values of fsa between the A and B molecules along this sequence (Fig. 12B, upper panel) are simply due to the absence of the C-terminal domain in the B chain model, which in the A chain folds back along H8 and partially occludes side chains from about N311 to T320. 

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