Obvious to try

Hydride reductions of C = N groups are well known in organic chemistry. It was therefore obvious to try to use chiral auxiliaries in order to render the reducing agent enantioselective [88]. The chiral catalyst is prepared by addition of a chiral diol or amino alcohol, and the active species is formed by reaction of OH or NH groups of the chiral auxiliary with the metal hydride. A major drawback of most hydride reduction methods is the fact that stoichiometric or higher amounts of chiral material are needed and that the hydrolyzed borates and aluminates must be disposed of, which leads to increased costs for the reduction step. 

The fact that some methods are obvious to try does not mean that the desired result is also obvious ... 

The problem of the removal of aerosol particles from gas streams has become of increasing importance from the standpoint of public health and the recovery of valuable products. Technology of controlling the aerosol particles or improving the liquid phase of aerosol is very important in many industrial processes such as oil and petroleum, electronic, mining, and food, as well as waste products like noxious emission of aerosol in chemical plants. There are several ways for this purpose among which fibrous filters are more popular so that it is obvious to try to improve their efficiency. The efficiency of collection and the pressure drop are the most important practical considerations in the design of these fibrous filters [2], Various... 

The EPO s Technical Board of Appeal has held that if the prior art very strongly and clearly directs the skilled person in a particular direction, there is no inventive step involved in following that direction, irrespective of the results. This is known as the one-way street situation and has led to considerable discussion amongst commentators. Obvious to try is not a standard for denying the existence of an inventive step. In accordance with recent practice in national Courts in Europe and in the United States, the EPO is reluctant to maintain an obvious to try objection in the face of unexpected results. 

Hydrogenation of MEA imine (Fig.4). Because the racemic metolachlor is produced via a reductive alkylation, it was obvious to try to hydrogenate the imine... 

About half of all present-day drugs are used as salts, and for the chemist it is obvious to try improving the properties of a drug candidate by the formation of a suitable salt, in particular with the intention to enhance solubility and in consequence, the rate of dissolution as prerequisite parameters for absorption. However, one should be aware, that high solubility alone does not guarantee good absorption. 

Rules of matrix algebra can be appHed to the manipulation and interpretation of data in this type of matrix format. One of the most basic operations that can be performed is to plot the samples in variable-by-variable plots. When the number of variables is as small as two then it is a simple and familiar matter to constmct and analyze the plot. But if the number of variables exceeds two or three, it is obviously impractical to try to interpret the data using simple bivariate plots. Pattern recognition provides computer tools far superior to bivariate plots for understanding the data stmcture in the //-dimensional vector space. 

As we said in the introduction, friction absorbs a lot of work in machinery and as well as wasting power, this work is mainly converted to heat at the sliding surfaces, which can damage and even melt the bearing. In order to minimise frictional forces we need to make it as easy as possible for surfaces to slide over one another. The obvious way to try to do this is to contaminate the asperity tips with something that (a) can stand the pressure at the bearing surface and so prevent atom-to-atom contact between asperities (b) can itself shear easily. 

It is a common experience in synthetic chemistry that a truly optimal ordering of a synthetic route may not be possible in the planning stage, but may have to determined experimentally. The precise information necessary for the complete and unambiguous evaluation of each step in a possible synthesis is hardly ever available. Nonetheless it is clearly wise to try to optimize a synthetic plan on the basis of available information before the experimental approach begins. Such an effort may suggest certain preliminary or "model" experiments that can be helpful in the choice or refinement of a synthetic plan. It is also obviously desirable to devise and consider alternate or bypass paths for each problematic step of a synthetic sequence. 

As the third major measurement to try to determine the remaining properties G 2 S, consider uniaxial tension loading at 45° to the 1-direction on a flat piece of iamina, i.e., a 45° off-axis test, as shown in Figure 2-26. By measurement of alone, obviously... 

Suppose a reaction is performed on a substrate molecule that can be represented as XGY, where Y is the site of the reaction, X a variable substituent, and G a skeleton group to which X and Y are attached, and we find that changing X from H to CH3 results in a rate increase by a factor, say, 10. We would like to know just what part of the increase is due to each of the effects previously mentioned. The obvious way to approach such a problem is to try to find compounds in which one or two of the factors are absent or at least negligible. This is not easy to do acceptably because factors that seem negligible to one investigator do not always appear so to another. The first attempt to give numerical values was that of Hammett. For the cases of m-and P-XC6H4Y, Hammett set up the equation... 

The first disconnection should be obvious and you might find it helpful to try and recognise a familiar product in the residual structure. 

The Gsp function is obvious. To obtain the load function Gload, set R = 0, and try to visualize the block diagram such that it is unity in the forward path and all the functions are in the feedback loop. 

One correct piece of advice though is not to try and increase the current limit of the switcher (that s an easy fix to the D > 0.5 problem—remove the offending current limit circuit altogether). The switch is clearly not rated for such high currents, nor has the company obviously evaluated the reliability under such conditions. So that warning is certainly fair and due. What s wrong is all the rest ... 

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