Obsessive-compulsive disorder predictors

Cummings, J.L. and Cunningham, K. (1992) Obsessive-compulsive disorder in Huntington s disease. Biol Psychiatry 31 263-270. Denckla, M.B. (1989) Neurological examination. In Rapoport, J.L., ed. Obsessive-Compulsive Disorder in Children and Adolescents. Washington, DC American Psychiatric Press, pp. 107-118. Douglass, H.M., Moffit, T.E., Dar, R., McGee, R., and Silva, P. (1995) Obsessive-compulsive disorder in a birth cohort of 18 year olds prevalence and predictors. / Am Acad Child Adoles Psychiatry 34 1424-1431. 

Predictors of drug treatment response in obsessive-compulsive disorder. / Clin Psychiatry 56 368—373. 

PREDICTORS OF TREATMENT OUTCOME IN OBSESSIVE-COMPULSIVE DISORDER... 

Studies of the use of the specific serotonin-uptake inhibitors (SSRIs) to treat OCD suggest that, compared to non-tic-related OCD, tic-related OCD is less responsive to SSRI monotherapy (McDougle et al., 1993, 1994). Addition of a neuroleptic, such as haloperidol (McDougle et ah, 1994), risperidone (McDougle et al., 2000), or olanzapine (Bogetto et al., 2000), appears to be useful in improving treatment-resistant individuals response to a SSRI. It is unclear whether this pattern of treatment response is specifically associated with a comorbid tic disorder the pattern of obsessive compulsive symptoms characteristic of TS or yet some other predictors. 

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