Obsessive-compulsive disorder buspirone

Grady TA, Pigott TA, L Heureux PL, et al Double-blind study of adjuvant buspirone for fluoxetine-treated patients with obsessive-compulsive disorder. Am J Psychiatry 150 819-821, 1993... 

Jenike MA Drug treatment of obsessive-compulsive disorder, in Obsessive Compulsive Disorders Theory and Management, 2nd Edition. Edited by Jenike MJ, Baer L, Minichiello WE. Littleton, MA, PSG Publishing, 1990, pp 249-282 Jenike MA, Baer L An open trial of Buspirone in OCD. Am J Psychiatry 145 1285-1286, 1988... 

Jenike MA, Baer L, Buttolph L Buspirone augmentation of fluoxetine in patients with obsessive compulsive disorder. J Clin Psychiatry 52 13-14, 1991a Jenike MA, Baer L, Ballantine HT, et al Cingulotomy for refractory obsessive-compulsive disorder a long-term follow-up of 33 patients. Arch Gen Psychiatry 48 548-555, 1991b... 

Joffe RT, Schuller DR An open study of buspirone augmentation of serotonin reuptake inhibitors in refractory depression. J Chn Psychiatry 54 269-271, 1993 Joffe RT, Singer W A comparison of triiodothyronine and thyroxine in the potentiation of tricyclic antidepressants. Psychiatry Res 32 241-251, 1990 Joffe RT, Swinson RP Carbamazepine in obsessive-compulsive disorder. Biol Psychiatry 22 1169-1171, 1987... 

Markovitz PJ, Stagno SJ, Calabrese JR Buspirone augmentation of fluoxetine in obsessive-compulsive disorder. Am J Psychiatry 147 798-800, 1990 Markowitz JS, Weissman PH, Ouelette R, et al Quality of life in panic disorder. Arch Gen Psychiatry 46 984-992, 1989... 

McDougle CJ, Goodman WK, Leckman JF, et al Limited therapeutic effect of addition of buspirone in fluvoxamine-refractory obsessive-compulsive disorder. Am J... 

Pato MT, Pigott TA, Hill JL, et al. Controlled comparison of buspirone and clomipramine in obsessive-compulsive disorder. Am J Psychiatry 1991 148 127-129. 

FIGURE 7—33. Mechanism of action of buspirone augmentation—pact 3. Shown here is how buspirone potentiates ineffective SSRI action at 5HT1A somatodendritic autoreceptors, resulting in the desired disinhibition of the 5HT neuron. This combination of 5HT1A agonists plus SSRIs may be more effective, not only in depression but also in other disorders treated by SSRIs, such as obsessive-compulsive disorder and panic. 

A) Alprazolam is effective in the management of obsessive-compulsive disorders Clonazepam has effectiveness in patients who suffer from phobic anxiety states Diazepam is used for chronic management of bipolar affective disorder in patients who are unable to tolerate lithium Intravenous buspirone is usefiil in status epilepticus... 

The azapirones have heen tested in panic disorder, obsessive compulsive disorder (OCD), drug-abuse and alcoholism. Gepirone, but not buspirone, was superior to placebo on panic attacks. Buspirone produced a significant improvement in OCD and reduced the craving and cigarette smokers, cocaine and phencyclidine users and alcoholists to some extent (for review see [2]). 

The full complement of anxiety syndromes including panic, generalized anxiety, obsessive-compulsiveness, and post-traumatic stress disorder can arise in the after-math of TBI. In fact, anxiety may be the most common neuropsychiatric complication of TBI. Anxiety appears to be most likely to arise when the injury occurs to the right side of the brain. The treatment alternatives for post-TBl anxiety parallel those used when treating anxiety disorders and include serotonin-boosting antidepressants, buspirone (Buspar), and the benzodiazepines (see Table 12.1). 

---