O-chlorobenzylidene

Chloroacetophenone (phenacyl chloride) Chlorbenzene (monochlorobenzene) o-Chlorobenzylidene malononitrile (OCBM) Chlorobromomethane/bromochloromethane 2-Chloro-l, 3-butadiene, see p-Chloroprene Chlorodiphenyl (42% chlorine)... 

Detailed Facts About Tear Agent o-Chlorobenzylidene Malononitrile (CS). Aberdeen Proving... 

A number of different cycloaddition reactions have been carried out on the C == N double bond of dihydrooxazines with the general structure 438 (Section II,A,5). With diphenylnitrilimine (DPNI), generated in situ from A-(o -chlorobenzylidene)-phenylhydrazine with triethylamine, the 1,2,4-triazolo[3,4-h][l,3]oxazines 439 were prepared (87MRC635, 87T1931, 87T5461). 

Toxicology. o-Chlorobenzylidene malononitrile (CS) aerosol is a potent lacrimator and upper respiratory irritant. 

The 2003 ACGIH ceiling-threshold limit value (C-TLV) for o-chlorobenzylidene malononitrile is 0.05ppm (0.39mg/m ) with a notation for skin absorption. 

Punte CL, Owens EJ, Gutentag PJ Exposure to or o-chlorobenzylidene malononitrile. Arch Environ Health 6 366-374, 1963... 

Wild D, Eckhardt K, Harnasch D, et al Geno-toxicity study of CS (ottZ o-chlorobenzylidene-malononitrile) in Salmonella, Drosophila and mice. Arch Toxicol 54 167-170, 1983... 

Ballantyne, B., Gall, D., and Robson, D.C. Effects on man of drenching with dilute solutions of o-chlorobenzylidene malono-nltrlle (CS) and dlbenz(b.f)-l 4-oxazeplne (CR). Med. Sci. 

P. The ophthalmic toxicology of o-chlorobenzylidene malononltrlle (CS). Arch. Toxicol. 32 149-168, 1974. 

Ballantyne, B. and Johnston, W.G. o-Chlorobenzylidene malono-nltrlle (CS) and the healing of cutaneous injuries. Med. 

Holland, P. and White, R.G. The cutaneous reactions produced by o-chlorobenzylidene malononitrile and w-chloroacetophenone when applied directly to the skin of human subjects. Br. J. Dermatol.86 150-154, 1972. 

Owens, E.J. and Punte, C. Human respiratory and ocular irritation studies utilizing o-chlorobenzylidene malononltrlle aerosols. Am. Ind. Hyg. Assoc. J. 24 262-264, 1963. 

Striker, G.E., Streett, C.S., Ford, D.F., Herman, L.H., and Helland, D.R. A clinlcopathological study of the effects of riot control agents on monkeys. V. Low concentrations of diphenylamlnochloroarslne (DM) or o-chlorobenzylidene malono-nitrile (CS) for extended periods. U.S. Army Medical Research Laboratory, Edgewood Arsenal, Md. Technical Report 4072. 

The iV-methylamine (160) (R = Me) gives a complex mixture of products when treated under the same conditions.186 It was shown subsequently that prior reduction of the anils used as starting materials is, in fact, unnecessary since in the presence of potassamide in liquid ammonia (o-chlorobenzylidene)aniline forms phenanthridine in excellent yield, and the analogous anils from p-toluidine and a-naphthylamine undergo ring closure under similar conditions. In view of the known trans geometry of the anils and the unlikelihood of trans-cis equilibration under these conditions this reaction deserves further study.187 Potassamide in liquid ammonia also converts 2-bromo-iV-ethyl-3 -hydroxybenzanilide (162) into a mixture of iV-ethyl-3-(164) and N-ethyl-1 -hydroxyphenanthridone (165), probably via the aryne (163).188... 

Although those acetals and ketals under consideration have not so far been employed extensively in industry, their industrial potentialities have not been overlooked, as the following four examples show. A color test based on tri-(o-chlorobenzylidene)-sorbitol has been used to detect the... 

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