O- Antigen synthesis

Bundle, D.R. Synthesis of Oligosaccharides Related to Bacterial O-Antigens. 154, 1-37 (1990). 

Bundle DR (1990) Synthesis of Oligosaccharides Related to Bacterial O-Antigens. 154 1-37 Buot FA (1996) Generalized Functional Theory of Interacting Coupled Liouvillean Quantum Fields of Condensed Matter. 181 173-210 Burke K, see Ernzerhof M (1996) 180 1-30 Burrell AK, see Sessler JL (1991) 161 177-274... 

Virlogeux, L Waxin, H. Ecobichon, C. Lee, J.O. Popoff, M.Y. Characterization of the rcsA and rcsB genes from Salmonella typhi rcsB through tviA is involved in regulation of Vi antigen synthesis. J. BacterioL, 178, 1691-1698 (1996)... 

L.V. (1981). Synthesis of the O-antigenic polysaccharide of Salmonella newington and of its analogue differing in configuration at the only glycosidic centre. Tetrahedron 37 Suppl. 1 19-156 Lehmann, V. (1977). Isolation, purification, and properties of an... 

Synthesis of Shigella flexneri O-Antigenic Repeating Units... 

Figure 1. Synthesis of a chemical repeating unit of the Shigella flexneri variant Y O-antigen, employing a sequential chain extension strategy.

Figure 2. Block synthesis of a tetrasaccharide repeating unit of the Y O-antigen.

The architectonics of O-antigenic polysaccharides unambiguously indicates that the most appropriate approach to their synthesis is to assemble the biopolymer out of prefabricated repeating units. The practical solution of this problem can be. achieved by several pathways (cf. 7) the following three most obvious ones will be discussed. 

The synthesis of the j>. newington O-antigenic polysaccharide by the chemical polymerization pathway will be discussed as an example (J 6 J 7) The first and the most difficult task consists in the preparation of the monomer itself, i. e. , the properly functionalized, oligosaccharide repeating unit. The most usual approach is to introduce the required functions into the already-existing oligosaccharide molecule. 

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