Nystatin reactions

Cooper SM, Reed J, Shaw S. Systemic reaction to nystatin. Contact Dermatitis 1999 41(6) 345-6. 

A recent example involves the synthesis of N-glycosyl derivatives of polyene macrolide antibiotics, such as the preparation of N-(deoxyfructosyl)nystatin (128) by reaction of nystatin with (+)-glucose (Scheme 30)."° 

IsolaHon of anUnes. Amino sugars have been isolated and purified as the N-carbobenzoxy derivatives. The group is removed by hydrogenolysis. Thus Winter-steiner and co-workers isolated crude mycosamine hydrochloride from hydrolysis of the antibiotic nystatin, but were unable to induce the material to crystallize. Reaction with carbobenzoxy chloride in aqueous sodium carbonate and extraction with ethyl acetate gave an oil and, when a solution of this in warm ethanol was chilled and scratched, colorless needles in clusters soon deposited. 

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