Nutraceuticals resveratrol

Table 3 Polymeric nanopaiticles used for encapsulating the nutraceutical resveratrol and their anticancer properties towards different cancer cells in vitro...

Diseases of the heart and circulatory system, cardiovascular diseases, have long been the leading cause of mortality in Europe and North America, and total cholesterol and low-density lipoprotein (LDL) cholesterol are the two most important risk factors for coronary heart disease. Decreased arterial compliance of the arteries is thought to contribute to systolic hypertension and coronary artery insufficiency. A number of nutraceuticals have been used for long-term prevention or symptom reduction in cardiovascular diseases, notably soy products, tea flavonoids, octacosanol, n-3-polyunsaturated fatty acids (PUFAs), and, to a lesser extent, melatonin, Pycnogenol, resveratrol, coenzyme QIO, lycopene, and DHEA. 

Nanoformulated nutraceuticals such as polyphenols and fiavanoids, which are derived from medicinal plants, provide a new insight for cancer treatment. The mechanism of action of these dietary agents in chemoprevention has gained considerable interest in the area of cancer research. This review has presented several mechanisms explaining the chemopreventive potentials of curcumin, EGCG, resveratrol, saponin, silymarin, and GSE. Their ability to target specific... 

In view of the increasing interest in resveratrol and its potential applications as a nutraceutical food supplement or cosmetic additive, biosyntheses of resveratrol and its derivatives, as well as the related metabolic engineering approaches including scaffolding strategy, have been discussed. 

In this article, we have reviewed the literatures available for the mechanism of action and anti-inflammatory properties of selected nutraceuticals such as curcumin, resveratrol, green tea polyphenols and diarylheptanoids (chemical structures in Figure 1). In addition we have also shown the antiinflammatory properties of a diarylheptanoids from Alpinia galanga and different possible targets in inflammation. 

The anti-inflammatory effects of nutraceuticals (curcumin, resveratrol, EGCG and other diaiylheptanoids) appear to be associated with their ability to inhibit NO, prosataglandins and cytokines. One of the most critical targets of these nutraceuticals involves NF-kB that regulates expression of a oIe variety of genes, such as COX-2, iNOS and proinflanunatory cytokines, responsible for inflammation (these targets are summarized in Figure 7). 

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