Nucleotidyltransferase superfamily

Structural analysis revealed a folding pattern (Class X) related to that of a nucleotidyltransferase superfamily that includes enzymes such as terminal deoxy-nucleotidyltransferase (Chapter 12) and the glutamine synthase adenylytransferase (Fig. 24-7). " However, its active site (Fig. 27-13) is similar to that of other DNA polymerases. 

Shuman S, Lima CD (2004) The polynucleotide ligase and RNA capping enzyme superfamily of covalent nucleotidyltransferases. Curr Opin Struct Biol 14 757-764. doi 10.1016/ j.sbi.2004.10.006... 

T. maritima (pdb IVLH), and the bifunctional PPAT/DPCK murine CoA synthase with acetyl-CoA bound (pdb 2F6R) have been determined. The crystal structures of bacterial PPAT enzymes show that they display sequence homology to members of the superfamily of nucleotidyltransferase a/(3 phosphodiesterases, which... 

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