Nucleotide UDP

The Sugar Nucleotide UDP-Glucose Donates Glucose for Glycogen Synthesis... 

It will be recalled that some of these UDP-N-acetylmuramyl compounds were isolated by Park and Johnson, from penicillin-inhibited cells of Staphylococcus aureus, at about the same time that Leloir s group isolated the first sugar nucleotide, UDP-D-glucose, from yeast. Other conditions also produce accumulation of some of these compounds. Thus, D-cycloserine is known to induce an accumulation of UDP-iV-acetylmuramy-tripeptide in S. aureus this is easily explained by the observation that D-cycloserine is a powerful, competitive inhibitor both of alanine racemase and D-alanyl-D-alanine synthetase. ... 

The nucleotide UDP-GNAc-lactyl-L-Ala-D-Glu-L-Lys accumulates in Staph, aureus treated with D-cycloserine. This accumulation is inhibited competitively by D-alanine, but not by its L-isomer. It has thus been suggested that the antibacterial activity of D-cycloserine (XXVIII) depends on its structural similarity to D-alanine, which enables it to inhibit the incorporation of the latter into the muramic acid-peptide of the cell wall. 

G is the designation for CaS04 binder. Silica G has been used to resolve pyridine nucleotides, UDP derivatives of hexosamines and acetylhexosamines. -H is without binder. PF2S4 is used for preparation of larger quantities of bases, nucleosides and many of their derivatives. Kieselguhrs are natural deposits of primarily silica, but may vary in both composition and size of particles. 

Synthesis of the CS/DS chains proceeds by the transfer of individual sugars from uridine sugar nucleotide (UDP) precursors. The major precursor activation path-... 

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