Nucleoside zinc complexes

The relative proportions of furanose and pyranose forms of aqueous 2-deoxy-2-fluoro-D-ribose at equilibrium have been determined with the help of H-, C-, and F-NMR spectroscopy.Recordings of vicinal C- P coupling constants were crucial for the determination of the configuration at phosphorus in the enantiomerically pure nucleoside phosphorothioates 40. After reassignment of the resonances for the phosphorus atoms in D-myn-inositol 1,2,6-trisphosphate, conclusions regarding the structure of its zinc complexes drawn previously on the basis of P-NMR titrations have been revised. 

Nucleophilic alkylation, C=0, C=N, and enones, 9, 192 Nucleophilic substitutions Sn2 processes, 9, 520, 9, 5249, 548-549 SnI processes, 10, 684 Sn2 processes, 10, 684 with titanium alkoxide complexes, 4, 273 Nucleoside dimers, via cross metathesis, 11, 194 Nucleoside kinases, in medicinal chemistry, 12, 458 Nucleosides, iodinated, into zinc reagents, 9, 82-83... 

Nucleobases and nucleosides are common motifs for hydrogen-bonded supramolecular arrays. Ng et al. first reported a series of phthalocyanine-nucleobase conjugates [64], The tetra-adenine phthalocyanine 64 was prepared by standard <9-alkylation of zinc(II) tetrahydroxyphthalocyanine with 9-(2-bromoethyl)adenine in the presence of K2CO3. The fluorescence of 64 is quenched substantially upon addition of thymine-substituted 9,10-anthraquinone 65, and the rate is much faster compared with that for the situation when the unsubstituted 9,10-anthraquinone is used as the quencher. These results suggest that 64 forms a supramolecular complex with 65 through the Watson-Crick base-pairing interactions. 

A number of zinc and cadmium complexes of adenine (82), " adenine JV-oxide, guanine, inosine, cytidine and other nucleosides have been studied. The structure of (9-methyladenine)ZnCl2 is polymeric each zinc ion is tetrahedrally coordinated to two chlorine atoms (Zn—Cl = 2.22 A), and to N-1 and N-7 of neighbouring adenine moieties (Zn— N = 2.05 A), A structural study of the related cadmium complex, CdCl2(DMSO (L = 9-methyladenine), has shown the complex to form a one-dimensional polymer. ... 

---