Nucleoside Analogs as Potential Drugs

Nucleoside Modifications 10.1.1.1 Nucleoside Analogs as Potential Drugs 

The development of nucleoside analogs for medicinal uses has had a marked impact on clinical chemotherapy, and numerous nucleoside analogs were successfully developed for the treatment of human immunodeficiency viruses (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), herpes simplex virus (HSV), cytomegalovirus (CMV), varicella zoster virus (VZV), and various cancers [1]. 

Based on these successes, several base- and sugar-modified nucleoside analogs bearing a triazole group at various positions have been prepared and evaluated. 

Click Reactions in Organic Synthesis, First Edition. Edited by Srinivasan Chandraseloiran. 

R = Ph, 4-MePh, Bn, alkyl, i oalkyl ferrocene, CH2OH, CH2NMe2 

---