Nucleobases binding

There have been few reports of purine derivatives1 that contain metal-carbon nucleobase binding (75), and those that have been described are often polymetalated (84). Quite recently mononuclear complexes of adenine and guanine have been prepared that contain... 

Peacock AFA, Melchart M, Deeth RJ, Habtemariam A, Parsons S, Sadler PJ (2007) Osmium (II) and mthenium(II) arene maltolato complexes rapid hydrolysis and nucleobase binding. Chem Eur J 13 2601-2613... 

Betanzos-Lara S, Salassa L, Habtemariam A, Sadler PJ (2009) Photocontrolled nucleobase binding to an organometallic Ru11 arene complex. Chem Commun 6622-6624... 

Effects of stacking interactions on the photoexcited triplet state of aromatic residues such as Trp are found over and above the external HAE described above. These effects are observed in protein/peptide-nucleic acid interactions in the absence of heavy atom derivatization of the nucleobases. Binding of Eco SSB to poly(dT) produces profound effects on the... 

Sarah Keller and a team mixed oily oxygen-tagged carbon chains. .. R. A. Black et al. Nucleobases bind to and stabilize aggregates of a prebiotic amphiphUe, providing a viable mechanism for the emergence of protocells. 2013. Proc Natl Acad Sci. 110(33), p. 13272. DOl 10.1073/pnas.l300963110. 

N, C, O), or indirectly via its others ligands. This latter possibility includes hydrogen bond formation—for example, between aqua or amine ligands and suitable acceptors of the nucleobase. A number of excellent reviews have been published about this topic. Taking into account the direct metal-nucleobase binding, a few general rules can be summarized ... 

The aim of the present chapter is to look at the structures of transition-metal-oxalate complexes with nucleobases as a valuable source of information on molecular recognition patterns controlling the formation of these systems. Therefore, we focus our attention not only on the metal-nucleobase binding modes but also on the intramolecular interligand interactions, which cooperate with the coordination bond in the stabilization of the resulting mixed-ligand complexes. 

In the zigzag polymeric chains of compounds [M(p-ox)(H20)(7/7-ade-KA )] 2(9i/-ade) (H20) (M° = Co, Zn), the adenine nucleobase binds to the metal centres through the less basic pyrimidinic N3 atom (Fig. 10) in contrast to what occurs in the previously described purine compounds where the organic ligands are coordinated through the imidazole N9 atom. 

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