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Nucleic acids genetic significance

The possibility of interfering with the structure or formation of nucleic acids with the aid of such antimetabolites obviously has great practical significance. An interference with growth of neoplastic tissue and influence on the genetic properties of an organism should be mentioned in the first place. [Pg.190]

The Genetic Significance of Nucleic Acids Transformation Is DNA-Mediated Structural Properties of DNA... [Pg.627]

Tt is well known that copper ions are required for the biological function of some enzymes and are detrimental to the function of many others. These effects can often be ascribed to conformational changes. The impact of copper ions on the conformation of nucleic acids is equally dramatic and of potential significance in disturbing the function of the genetic material (1, 2). [Pg.306]

We present experimental results on photophysical deactivation pathways of uracil and thymine bases in the gas phase and in solvent/solute complexes. After photoexcitation to the S2 state, a bare molecule is tunneled into and trapped in a dark state with a lifetime of tens to hundreds of nanoseconds. The nature of this dark state is most likely a low lying nn state. Solvent molecules affect the decay pathways by increasing IC from the S2 to the dark state and then further to the ground state, or directly from S2 to S0. The lifetimes of the S2 state and the dark state are both decreased with the addition of only one or two water molecules. When more than four water molecules are attached, the photophysics of these hydrated clusters rapidly approaches that in the condensed phase. This model is now confirmed from other gas phase and liquid phase experiments, as well as from theoretical calculations. This result offers a new interpretation on the origin of the photostability of nucleic acid bases. Although we believe photochemical stability is a major natural selective force, the reason that the nucleic acid bases have been chosen is not because of their intrinsic stability. Rather, it is the stability of the overall system, with a significant contribution from the environment, that has allowed the carriers of the genetic code to survive, accumulate, and eventually evolve into life s complicated form. [Pg.317]


See other pages where Nucleic acids genetic significance is mentioned: [Pg.9]    [Pg.40]    [Pg.250]    [Pg.569]    [Pg.84]    [Pg.291]    [Pg.627]    [Pg.628]    [Pg.628]    [Pg.993]    [Pg.82]    [Pg.695]    [Pg.16]    [Pg.193]    [Pg.229]    [Pg.4]    [Pg.112]    [Pg.4]    [Pg.170]    [Pg.388]    [Pg.42]    [Pg.199]    [Pg.37]    [Pg.1201]    [Pg.44]    [Pg.93]    [Pg.271]    [Pg.263]    [Pg.368]    [Pg.259]    [Pg.299]    [Pg.309]    [Pg.128]    [Pg.321]    [Pg.52]    [Pg.607]    [Pg.341]    [Pg.291]    [Pg.187]    [Pg.262]    [Pg.263]    [Pg.6]    [Pg.585]    [Pg.575]   
See also in sourсe #XX -- [ Pg.628 ]




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