Nuclear receptors, retinoid-induced gene activation

The discovery of nuclear RARs has introduced a novel method for evaluating the potential carcinostatic activity of a new retinoid [81,84-88], This can be done by measuring the ability of a retinoid either to bind to the RARs [84,85,87,88] or to induce activation of reporter genes via an RAR [81,86-88]. The affinity of retinoids for nuclear receptors in HL-60 cells appears to correlate well with anti-APL activity in vitro [94,95] as discussed in the next section. In general, a good correlation between retinoid carcinostatic activity and ability to bind to or activate retinoic acid receptors appears to exist. 

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