Nuclear magnetic resonance restraints

Because of the conformational restraints imposed on the cycloamyloses by their looped arrangement, it is reasonable to assume that the structural features derived for the crystalline state will be retained in solution. This has been confirmed in recent years by means of a variety of spectroscopic techniques. Nuclear magnetic resonance (Rao and Foster, 1963 Glass,... [Pg.211]

The most important advance in determining the structures of proteins in recent years has been the development of high-field nuclear magnetic resonance methods.9,10 These methods enable us to determine the structures of moderately sized (< 30 kDa) proteins in solution.11,12 The principle of the method is quite different from x-ray crystallography in that the overall structure is calculated principally from restraints on the distances between 1H atoms. [Pg.341]

D. A. Pearlman and P. A. Kollman, / Mol. Biol., 220, 457 (1991). Are Time-Averaged Restraints Necessary for Nuclear Magnetic Resonance Refinement ... [Pg.169]

A method for solving the three-dimensional structures of protein-protein complexes in solution on the basis of experimental nuclear magnetic resonance (NMR) restraints pro-... [Pg.15]

Nadaud PS, Helmus JJ, Hofer N, Jaroniec CP (2007) Long-range structural restraints in spin-labeled proteins probed by solid-state nuclear magnetic resonance spectroscopy. J Am Chem... [Pg.199]

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