Nuclear magnetic resonance deuterium exchange

Nuclear magnetic resonance may yield identification of histidine by deuterium exchange (N-H versus N-D) at or near the metal, especially if paramagnetic.252 The resonances are moved away from the 0-10 ppm region as a result of a paramagnetic center in proximity. 

Kamel AM, Zandi KS, Massefski WW. 2003. Identification of the degradation product of ezlopitant, a non-peptidic substance P antagonist receptor, by hydrogen deuterium exchange, electrospray ionization tandem mass spectrometry (ESI/MS/MM) and nuclear magnetic resonance (NMR) spectroscopy. J Pharm Biomed Anal 31 1211. 

F. Nuclear Magnetic Resonance Spectra and Deuterium Exchange 90... 

R. M. Smith, O. Chienthavorn, S. Saha, I. D. Wilson, B. Wright, and S. D. Taylor, Selective deuterium exchange during superheated heavy water chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry of sulfonamides, /. Chromatogr. A 886 (2000), 289-295. 

Nuclear magnetic resonance NMR Quantized orientation of nuclear spin in a magnetic field. Energy separations sampled with radiofrequency radiation. Identification of histidine by deuterium exchange (N—H vs. N—D) at or near metal, especially if paramagnetic. 

The assignment of these isomers was confirmed by nuclear magnetic resonance spectroscopy on a Perkin-Elmer 60 Mc./sec. NMR spectrometer, after removal of -OH by exchange with deuterium oxide. The spectrum of the cw-alcohol showed a single broad peak, while that of the trans-alcohol showed two peaks they thus resembled the spectra of the corresponding hydrocarbons (8). 

Deuterium NMR Studies on Thermopiastic Eiastomers. For the investigation of the molecular dynamics in polymers, deuteron solid-state nuclear magnetic resonance ( D-NMR) spectroscopy has been shown to be a powerful method (2). In the field of viscoelastic polymers, segmental dynamics of poly(urethanes) has been studied intensively by D-NMR (131,132). In addition to ID NMR Spectoscopy, 2D NMR exchange spectroscopy was used to extend the time scale of molecular dynamics up to the order of milliseconds or even seconds. In combination with line-shape simulation, this technique allows one to obtain correlation times and correlation-time distributions of the molecular mobility as well as detailed information about the geometry of the motional process (2). 

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