Nuclear hormone receptor genes

Nagy L, Kao HY, Love DJ, Li C, Banayo E, et al. 1999. Mechanism of corepressor binding and release from nuclear hormone receptors. Genes Dev. 13 3209-16... 

Ribeiro RCJ, Kushner PJ, Baxter JD. The nuclear hormone-receptor gene superfamily. An Rev Med 1995 46 443-53. 

NSF, see National Science Foundation Nuclear hormone receptor genes, 272 Null hypothesis, 58 Numerical taxonomy, 127 development of, 6 validity of, 7... 

Once nuclear hormone receptors are bound to their hormone, they are capable of being integrated directly into the machinery that regulates the transcription of specific genes. This action is more direct, and apparently more... 

The final phase of action of the hormones that utilize nuclear hormone receptors lies in the modification of the gene transcription. In spite of the enormous... 

The KS mutations were identified in the KAL gene and result in abnormal olfactory bulb development (99,100). The mutations responsible for the X-linked IHH with adrenal hypoplasia congenita were identified in the DAXl gene. DAXl encodes an orphan nuclear hormone receptor that regulates portions of reproductive development (101,102). 

Nuclear hormone receptors, including those for the principal classes of steroids, retinoids, vitamin D, and thyroid hormones, are transcription factors that influence gene expression. 

J. Chiang, Bile acid regulation of gene expression. Roles of nuclear hormone receptors. Endocrine Reviews, 2002, 23(4), 443 63. 

Fig. 4 Co-activator and co-repressor complexes are required for nuclear hormone receptor-mediated transcriptional regulation. The tissue-selective fine-tuning of gene transcription by nuclear hormone receptors is due to different co-regulatory complexes that have various functions and enzymatic activities. Co-activator complexes include factors that contain ATP-dependent chromatin remodelling activity often associated with histone acetyltransferase (HAT) activity. Co-repressors include ATP-dependent chromatin remodelling complexes, which function as platforms for the recruitment of several subcomplexes that often contain histone deacetylase (HDAC) activity...

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