Nuclear factor apoptosis role

Gupta S, Hastak K, Afaq F, Ahmad N, Mukhtar H. 2004. Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis. Oncogene 23 2507-2522. 

Mclnnis J., Wang C., Anastasio N., Hultman M., Ye Y., Salvemini D., and Johnson K. M. (2002). The role of superoxide and nuclear factor-/cB signaling in M-methyl-D-aspartate-induced necrosis and apoptosis. J. Pharmacol. Exp. Ther. 301 478 187. 

The 5-HT1A receptor can regulate a number of ERK-related effectors including activation of PI3 -K (43 6), stimulation of NF-KB (nuclear factor-KB) (50), and inhibition of caspase 3 (43,51). The inhibition of caspase 3 is crucial for 5-HT1A-mediated attenuation of anoxia-induced apoptosis (51), suggesting that the 5-HT1A receptor could play a potential role in neuronal survival. 

The transcription factor nuclear factor kappa B (NF-kB) is a member of the Rel family of proteins that plays an important role in a variety of cellular response mechanisms including immunity, inflammation, cell growth, and apoptosis. Recent evidence suggests that this transcription factor is induced following exposure of cancer cells to apoptotic... 

Marma, S.K. and Aggarwal, B.B., Lipopolysaccharide inhibits TNF-induced apoptosis role of nuclear factor-kappaB activation and reactive oxygen intermediates, J. Immunol, 162 (3), 1510-1518, 1999. 

Apoptosis can be triggered by mitochondrial damage, which is followed by the release of cytochrome c and the caspase cascade [167], The BAX protein activates mitochondrial release of cytochrome c [168], while Bcl-2 is a mitochondrial protein inhibits the apoptotic process and promotes cell survival [169]. Ji et al. [163] research showed that occur a decrease in mitochondrial Bcl-2 and a markedly increase in mitochondrial level of Bax in the HepG2 cells treated with PA from 200 to 400 mM concentrations. The authors suggest that this mechanism can contribute to NASH and NAFLD installation, and especially may play an important role in the transition from steatosis to steatohepatitis in human. Other studies [170] on the effect of FAs-induced steatosis on cellular apoptosis have demonstrated that palmitic and oleic FA mixtures-induced steatosis is associated with apoptosis in hepatocyte cell cultures. Joshi-Barve s et al. [171] studies also showed that exposure to excess palmitic acid induces apoptosis and lL-8 production in hepatocytes in a relation of dose-dependent and time dependent manner, via activation of c-Jun amino terminal kinase (JNK/AP-1), and nuclear factor kappa B (NF-B) transcription factors for IL-8 expression. 

Jazirehi, A.R., Huerta-Yepez, S., Cheng, G., and Bonavida, B. (2005). Rituximab (chimeric anti-CD20 monoclonal antibody) inhibits the constitutive nuclear factor- kappa )B signaling pathway in non-Hodgkin s lymphoma B-cell lines role in sensitization to chemotherapeutic drug-induced apoptosis. Cancer Res. 65, 264-276. 

Manna SK, Mukhopadhyay A, Aggarwal BB. 2000. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-k B, activator protein-1, and apoptosis Potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol 164 6509-6519. 

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