Nuclear chemistry cancer treatment with

Aside from the well-recognized role of retinoids in the chemistry of vision,they bind to, and therefore activate, up to six intracellular retinoid receptors (the RARs and RXRs)J" In doing so they serve as modulators of nuclear transcription, which impacts numerous cellular events (e.g., reproduction, immune function, and development). Such actions have consequences for treatment of certain cancers, including leukemia, melanoma, Kaposi s sarcoma, and squamous cell carcinoma. Several approaches to both natural and unnatural retinoids, which make use of a Pd(0)-induced vinyl-vinyl cross-coupling, have appeared over the last decade, with extensive woik ongoing given the connection to oncology. 

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