NSAIDs Statins

Cardiovascular Keep doses of NSAIDs and glucocorticoids low, consider initiation of folic acid to reduce homocysteine level elevations induced by methotrexate, consider initiation of low-dose aspirin and/or HMG-CoA reductase inhibitors (statins), and encourage smokers to discontinue tobacco use and assist with the development of a tobacco-cessation plan.11,12... 

NSAIDs), specific classes of antibiotics (e.g., sulfa drugs) and statin lipid-lowering agents [107]. 

NSAIDS and a Statin . Benzene rings provide the aromatic nucleus for the majority of the NSAIDs. A propionic acid attached at its 2 position provides the side chain for most of these compounds, as noted in Chapter 2. Inhibition of the cyclooxygenase enzyme and consequently NSAID activity is retained when the role of an aromatic ring is filled by a pyrrole. The side chain for all but one of those compounds, it should be noted, consists of an otherwise unsubstituted acetic acid. 

The use of statins and probably fibrates should be suspended during daptomycin use because of the possible increased risk of muscle toxicity. Daptomycin does not appear to interact with warfarin, but its use may result in falsely elevated prothrombin times. NSAIDs may reduce daptomycin excretion and concurrent use may increase the risks of renal impairment... 

---